RORα in genetic control of cerebellum development:: 50 staggering years

The staggerer mutation was first identified at the Jackson Laboratory in 1955. In the ensuing half-century, studies of staggerer mice have provided new insights into developmental neurobiology, gene regulatory networks, and circadian behavior. Recent work has expanded the role of ROR alpha, the transcription factor mutated in staggerer, to peripheral tissues, including cholesterol and lipid metabolism, immune function, and bone development. This review focuses on the role of ROR alpha in neural development and behavior revealed by the staggerer mutation and subsequent molecular studies. (c) 2005 Elsevier B.V. All rights reserved.