Journal
CARBOHYDRATE RESEARCH
Volume 342, Issue 5, Pages 696-703Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2006.12.021
Keywords
multivalent neoglycoconjugates; oligosaccharide mimetics; fluorescence labeling; squaric acid coupling
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Functionalized carbohydrate-centered glycoclusters formed the starting material for the synthesis of tagged oligosaccharide and glycoconjugate mimetics, which were obtained by thiourea-bridging, peptide coupling and in particular squaric diester-mediated coupling. The latter method could also be utilized to provide new multivalent glycoconjugates, which were tested for their anti-adhesive properties in an ELISA with Escherichia coli bacteria. (c) 2007 Elsevier Ltd. All rights reserved.
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