Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 104, Issue 15, Pages 6261-6265Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0700471104
Keywords
phylogeny; retrovirus; ERV; rabbit
Categories
Funding
- MRC [G90/77] Funding Source: UKRI
- Medical Research Council [G90/77] Funding Source: Medline
- Medical Research Council [G90/77] Funding Source: researchfish
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The lentiviruses are associated with a wide range of chronic diseases in mammals. These include immunodeficiencies (such as HIV/AlDS in humans), malignancies, and lymphatic and neurological disorders in primates, felids, and a variety of wild and domesticated ungulates. Evolutionary analyses of the genomic sequences of modern-day lentiviruses have suggested a relatively recent date for their emergence, but the failure to identify any enclogenous, vertically transmitted examples has meant that their longer term evolutionary history and origin remain unknown. Here we report the discovery and characterization of retroviral sequences belonging to a new lentiviral subgroup from the European rabbit (Oryctolagus cuniculus). These viruses, the first enclogenous examples described, are > 7 million years old and thus provide the first evidence for an ancient origin of the lentiviruses. Despite being ancient, this subgroup contains many of the features found in present-day lentiviruses, such asthe presenceof tatand revgenes, thusalso indicating an ancientorigin forthe complex regulation of lentivirus gene expression. Although the virus we describe is defective, reconstruction of an infectious progenitor could provide novel insights into lentivirus biology and host interactions.
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