Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 43, Issue 5, Pages 1692-1699Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2006.12.032
Keywords
LC-MS; CID MS/MS; characterization; PMFs; Fructus aurantii
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Atmospheric pressure chemical ionization mass spectrometry (APCI-MS) was operated in positive mode (PI) to characterize polymethoxylated flavonoids (PMFs) through its specific radical cations by collision-induced dissociation (CID). The fragments of [M + H - n x 15](+) produced by loss of one or more methyl group from the protonated molecule, as well as [M + H - 29](+), [M + H - 31](+), [M + H - 33](+), [M + H - 43](+), [M + H - 46](+), and [M + H - 61](+) fragment ions were detected, which were diagnostic for the polymethoxylated species, and could be adopted to form the multiple MS (MSn) fingerprint of PMFs. Based on this fingerprint, 29 PMFs were screened out from extracts of Fructus aurantii, among which two of them were identified as sinensetin and tangeretin. It was proved that the PI was suitable for structural characterization of PMFs by APCI-MSn. (c) 2007 Elsevier B.V. All rights reserved.
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