Journal
ORGANIC LETTERS
Volume 9, Issue 8, Pages 1525-1528Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol070294u
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Funding
- NCI NIH HHS [CA44848] Funding Source: Medline
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[GRAPHICS] Two new cyclic peptides, thalassospiramides A and B (1 and 2), were isolated from a new member of the marine alpha-proteobacterium Thalassospira. The thalassospiramides, the structures of which were assigned by combined spectral and chemical methods, bear unusual gamma-amino acids and show immunosuppressive activity in an interleukin-5 production inhibition assay (IC50 = 5 mu M for thalassospiramide B).
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