Neoglycopeptide dendrimer libraries as a source of lectin binding ligands

A 15 625-membered peptide dendrimer combinatorial library was acylated with an alpha-C-fucosyl residue at its four N-termini and screened for binding to fucose-specific lectins. Dendrimer FD2 (Fuc-alpha-CH2CO-Lys-Pro-Leu)(4)(Lys-Phe-Lys-Ile)(2)Lys-His-Ile-NH2 was identified as a potent ligand against Ulex europaeus lectin UEA-I (IC50 = 11 mu M) and Pseudomonas aeruginosa lectin PA-IIL (IC50 = 0.14 mu M).