Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 72, Issue 8, Pages 3129-3132Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo0625094
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A highly efficient secondary benzylation procedure has been demonstrated using a high-valent heterobimetallic complex [Ir-2(COD)(2)(SnCl3)(2)(Cl)(2)(mu-Cl)(2)] 1 as the catalyst in 1,2-dichloroethane to afford the corresponding benzylated products in moderate to excellent yields. The reaction was performed not only with carbon nucleophiles (arenes and heteroarenes) but also with oxygen (alcohol), nitrogen (amide and sulfonamide), and sulfur (thiol) nucleophiles. Mechanistic investigation showed the intermediacy of the ether in this reaction. An electrophilic mechanism is proposed from Hammett correlation.
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