Journal
MOLECULAR CELL
Volume 26, Issue 1, Pages 75-87Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2007.02.019
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Funding
- NCI NIH HHS [CA16672, CA099031, P30 CA016672, P01 CA099031, R01 CA109311, R01 CA109311-03, CA109311, P01 CA099031-04] Funding Source: Medline
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CBP plays a central role in coordinating and integrating multiple signaling pathways. Competition between NF-kappa B and p53 for CBP is a crucial determinant of whether a cell proliferates or undergoes apoptosis. However, how the CBP-dependent crosstalk between these two transcription factors is regulated remains unclear. Here, we show that IKK alpha phosphorylates CBP at serine 1382 and serine 1386 and consequently increases CBP's HAT and transcriptional activities. Importantly, such phosphorylation enhances NF-kappa B-mediated gene expression and suppresses p53-mediated gene expression by switching the binding preference of CBP from p53 to NF-kappa B, thus promoting cell growth. The CBP phosphorylation also correlates with constitutive IKK alpha activation in human lung tumor tissue compared with matched nontumor lung tissue. Our results suggest that phosphorylation of CBP by IKK alpha regulates the CBP-mediated crosstalk between NF-kappa Band p53 and thus may be a critical factor in the promotion of cell proliferation and tumor growth.
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