Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 72, Issue 8, Pages 2851-2856Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo062436o
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM067610-03, R01 GM067610] Funding Source: Medline
Ask authors/readers for more resources
An efficient and general procedure was developed for the direct alkylation of H-phosphinate esters with LHMDS at low temperature. The simplicity of the reaction allows the use of various H-phosphinate esters and takes place with a wide range of electrophiles. The approach can be employed to access some GABA analogues or precursors to GABA analogues. The isolated yields are moderate to good. This is the first report of an alkylation with a secondary iodide or a primary chloride.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available