Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 849, Issue 1-2, Pages 261-272Publisher
ELSEVIER
DOI: 10.1016/j.jchromb.2006.09.033
Keywords
experimental design; differential analysis; proteomics; two-dimensional gel electrophoresis
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Proteomics relies on the separation of complex protein mixtures using bidimensional electrophoresis. This approach is largely used to detect the expression variations of proteins prepared from two or more samples. Recently, attention was drawn on the reliability of the results published in literature. Among the critical points identified were experimental design, differential analysis and the problem of missing data, all problems where statistics can be of help. Using examples and terms understandable by biologists, we describe how a collaboration between biologists and statisticians can improve reliability of results and confidence in conclusions. (c) 2006 Elsevier B.V. All rights reserved.
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