Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 195, Issue 8, Pages 1177-1180Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/512682
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Funding
- NIAID NIH HHS [AI 38518] Funding Source: Medline
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We investigated the effect of human immunodeficiency virus type 1 (HIV-1) subtype on disease progression among 145 Kenyan women followed from the time of HIV-1 acquisition. Compared with those infected with subtype A, women infected with subtype D had higher mortality ( hazard ratio, 2.3 [95% confidence interval, 1.0-5.6]) and a faster rate of CD4 cell count decline (P=.003). The mortality risk persisted after adjustment for plasma HIV-1 load. There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a 12-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads.
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