Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 15, Issue 8, Pages 2920-2926Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2007.02.015
Keywords
marine natural products; amino alcohols; cytotoxic compounds; ascidians
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The chemical investigation of the Mediterranean ascidian Clavelina phlegraea has led to the isolation of six new 2-amino-3-alkanol derivatives, clavaminols A-F (1-6). Their stereo structures were established by analysis of spectroscopic data and chemical conversion. Clavaminols A, B, C, and F were tested for their cytotoxic and pro-apoptotic properties and clavaminol A was shown to be the more potent cytotoxic compound of this series inducing cell death through activation of the apoptotic machinery. (c) 2007 Elsevier Ltd. All rights reserved.
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