Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 15, Issue 8, Pages 2878-2882Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2007.02.019
Keywords
Sarcodon cyrneus; cyrneine C; cyrneine D; glaucopine C; cyathane diterpenes; NGF expression; PC12; neurite outgrowth
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Two new cyathane diterpenes, cyrneine C (4) and D (5), were isolated from the mushroom Sarcodon cyrneus, along with previously isolated cyrneine A, B and glaucopine C. The structures of the novel diterpenoids were determined by the analysis of spectroscopic data. Effects of the cyrneines and glaucopine C on the NGF gene expression in 1321N1 cells and on neurite outgrowth on PC12 cells were evaluated. (c) 2007 Elsevier Ltd. All rights reserved.
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