Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 56, Issue 1-2, Pages 174-181Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2006.12.019
Keywords
magnetic resonance imaging; tumor; contrast agent; beta-FeOOH; poly(ethylene glycol); block copolymer; zeta potential; FT-IR
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PEG-coated P-FeOOH nanoparticles were prepared through electrostatic complex formation of iron oxide nanoparticles with poly(ethylene glycol)-poly(aspartic acid) block copolymer [PEG-P(Asp)] in distilled water. By dynamic light scattering (DLS) measurement, the nanopaticle size was determined to be 70 nm with narrow distribution. The FT-IR and zeta potential experimental results proved that PEG-PAsp molecules bound to the surface of the iron oxide nanoparticles via the coordination between the carboxylic acid residues in the PAsp segment of the block copolymer and the surface Fe of the P-FeOOH nanoparticles. The PEG-coated nanoparticles revealed excellent solubility and stability in aqueous solution as well as in physiological saline. In vivo MRI experiments on tumor-bearing mice demonstrated that the PEG-coated nanoparticles prepared by the current approach achieved an appreciable accumulation into solid tumor, suggesting their potential utility as tumor-selective MRI contrast agents. (c) 2007 Elsevier B.V. All rights reserved.
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