Journal
JOURNAL OF IMMUNOLOGY
Volume 178, Issue 8, Pages 5173-5181Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.178.8.5173
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Funding
- NIAID NIH HHS [P01 AI 0577484, R01 AI 49309, AI 057159, U54 AI057159] Funding Source: Medline
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TLRs are important components of the innate immune response. The role of the TLR signaling pathway in host defense against a natural viral infection has been largely unexplored. We found that mice lacking MyD88, an essential adaptor protein in TLR signaling pathway, were extremely sensitive to intranasal infection with vesicular stomatitis virus, and this susceptibility was dose dependent. We demonstrated that this increased susceptibility correlates with the impaired production of IFN-alpha and defective induction and maintenance of neutralizing Ab. These studies outline the important role of the TLR signaling pathway in nasal mucosae-respiratory tracts-neuroepithelium environment in the protection against microbial pathogen infections. We believe that these results explain how the route of infection, probably by virtue of activating different cell populations, can lead to entirely different outcomes of infection based on the underlying genetics of the host.
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