Readily available amino acid building blocks for the synthesis of phosphole-containing peptides

Nucleophilic substitution of a phospholide anion onto protected 3-iodoalanine leads to the formation of an amino acid with an appended phosphole in excellent yield. Manipulation of the protecting groups, leads to building blocks suitable for the synthesis of phosphole-containing polypeptides. (c) 2007 Elsevier Ltd. All rights reserved.