Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 179, Issue 1, Pages 1-18Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2007.01.023
Keywords
stress; anxiety; depression; experimental (animal) models and tests; exploration; obsessive-compulsive behaviors; stereotypies; paradigm shifts
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Stress plays a key role in pathogenesis of anxiety and depression. Animal models of these disorders are widely used in behavioral neuroscience to explore stress-evoked brain abnormalities, screen anxiolytic/antidepressant drugs and establish behavioral phenotypes of gene-targeted or transgenic animals. Here we discuss the current situation with these experimental models, and critically evaluate the state of the art in this field. Noting a deficit of fresh ideas and especially new paradigms for animal anxiety and depression models, we review existing challenges and outline important directions for further research in this field. (c) 2007 Elsevier B.V. All rights reserved.
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