Journal
CIRCULATION
Volume 115, Issue 15, Pages 2049-2054Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCULATIONAHA.106.665570
Keywords
adventitia; angiogenesis; arteriosclerosis; atherosclerosis; stem cells
Funding
- NHLBI NIH HHS [U01 HL080711, R01 HL70531, P01 HL58000] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008169] Funding Source: Medline
Ask authors/readers for more resources
Background-Recent studies have suggested a potential contribution of bone marrow-derived progenitor cells to vascular repair. Preliminary clinical studies have explored the possibility that mobilization of progenitor cells with granulocyte macrophage colony-stimulating factor ( GM-CSF) and granulocyte colony-stimulating factor ( G-CSF) can affect vascular repair. However, it is not known whether the short-term administration of G-CSF or GM-CSF exerts beneficial effects on atherosclerosis. Methods and Results-Apolipoprotein E-deficient mice were treated with either GM-CSF or G-CSF at a dose of 10 mu g . kg(-1) . d(-1) SC administered daily for 5 days per week on alternating weeks for a total of 20 doses over an 8-week treatment period. We found that in animals maintained on a high-fat diet, both G-CSF and GM-CSF actually demonstrated an increase in atherosclerotic lesion extent. The increase in atherosclerotic extent was not associated with an increase in either inflammatory cells or expression of proinflammatory genes. Interestingly, adventitial vascularity significantly increased, suggesting a mechanistic role for vasa vasorum neovascularization. Conclusions-These findings demonstrate that in this animal model of atherosclerosis, not only did administration of G-CSF or GM-CSF fail to demonstrate any beneficial therapeutic effect, but both resulted in a worsening of atherosclerosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available