Journal
NEUROSCIENCE LETTERS
Volume 416, Issue 3, Pages 252-256Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2007.01.067
Keywords
proteomics; hippocampus; major depression disorders; MALDI-TOF-MS
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Major depression is one of the most disabling disorders. Yet, the pathogenesis of this mental disorder is poorly understood. Hippocampus is generally believed to be associated with pathogenesis of depression. In this study, we adopted a proteomic approach to examine possible alterations of protein expression in the hippocampus of a rat depression model. Our results suggest that neurogenesis in hippocampus may play an important role in the pathogenesis of major depression. (c) 2007 Elsevier Ireland Ltd. All fights reserved.
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