Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 15, Pages 4701-4705Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja068654g
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Funding
- Medical Research Council [G0300122] Funding Source: Medline
- Medical Research Council [G0300122] Funding Source: researchfish
- MRC [G0300122] Funding Source: UKRI
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A robust, portable chip containing a single protein nanopore would be a significant development in the practical application of stochastic sensing technology. Here, we describe a chip in which a single alpha-hemolysin (alpha HL) pore in a planar phospholipid bilayer is sandwiched between two layers of agarose gel. These encapsulated nanopore chips remain functional after storage for weeks. The detection of the second messenger inositol 1,4,5-trisphosphate (IP3) was demonstrated with a chip containing a genetically engineered alpha HL pore as the sensor element.
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