4.8 Article

Combinatorial rosamine library and application to in vivo glutathione probe

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 15, Pages 4510-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja068230m

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Funding

  1. NCRR NIH HHS [C06 RR 16572] Funding Source: Medline
  2. NIGMS NIH HHS [P20 GM 072029] Funding Source: Medline

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Combinatorial approach on fluorescent rosamine library was developed using solid-phase chemistry. A highly selective library member (H22) toward reduced glutathione (GSH) was discovered, demonstrating the capability of in vivo GSH level sensing in live cells.

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