Preliminary studies on antihepatotoxic effect of Physalis peruviana Linn. (Solanaceae) against carbon tetrachloride induced acute liver injury in rats

Physalis peruviana is a medicinal herb used by Muthuvan tribes and Tamilian native who reside in the shola forest regions of Kerala, India against jaundice. It was evaluated for its antihepatotoxic, phytochemical analysis and the acute toxicity of the most promising extract in rats. Water, ethanol and hexane extracts of Physalis peruviana (500 mg/kg body weight) showed antihepatotoxic activities against CCl4 induced hepatotoxicity. The ethanol and hexane extracts showed moderate activity compared to water extract, which showed activity at a low dose of 125 mg/kg. The results were judged from the serum marker enzymes. Histopathological changes induced by CCl4 were also significantly reduced by the extract. Further, the extract administration to rats resulted in an increase in hepatic GSH and decrease in NIDA. Preliminary phytochemical analysis revealed the presence of various components in the crude aqueous extract. The extract was found to be devoid of any conspicuous acute toxicity in rats. (c) 2006 Elsevier Ireland Ltd. All rights reserved.