Journal
VIROLOGY
Volume 361, Issue 1, Pages 133-140Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2006.11.008
Keywords
tobamovirus; movement protein; cell-to-cell movement; brefeldin A; ER-to-Golgi pathway; plasmodesmata
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It has been demonstrated that the subcellular location of Tobamovirus movement protein (NIP) which was fused with green fluorescent protein (MP:GFP) changed during the infection process. However, the intracellular route through which NIP is transported and its biological meaning are still obscure. Treatment with brefeldin A (BFA), which disrupts ER-to-Golgi transport, inhibited the formation of irregularly shaped and filamentous structures of MP In this condition, MP was still targeted to plasmodesmata in leaf cells. Furthermore, the viral cell-to-cell movement was not inhibited by BFA treatment. These data indicated that the targeting of viral replication complexes (VRCs) to plasmodesmata is mediated by a BFA-insensitive pathway and that the ER-to-Golgi transport pathway is not involved in viral intercellular movement. (c) 2006 Elsevier Inc. All rights reserved.
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