Journal
SCIENCE
Volume 316, Issue 5824, Pages 597-600Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1138595
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Funding
- NIGMS NIH HHS [GM057422, GM70956] Funding Source: Medline
- NINDS NIH HHS [NS042580, NS048396] Funding Source: Medline
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One proposed strategy for controlling the transmission of insect-borne pathogens uses a drive mechanism to ensure the rapid spread of transgenes conferring disease refractoriness throughout wild populations. Here, we report the creation of maternal-effect selfish genetic elements in Drosophila that drive population replacement and are resistant to recombination-mediated dissociation of drive and disease refractoriness functions. These selfish elements use microRNA-mediated silencing of a maternally expressed gene essential for embryogenesis, which is coupled with early zygotic expression of a rescuing transgene.
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