Journal
MOVEMENT DISORDERS
Volume 22, Issue 6, Pages 839-842Publisher
WILEY-LISS
DOI: 10.1002/mds.21413
Keywords
smell; olfaction; neurodegeneration; anosmia.
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Recent studies support the idea of olfactory dysfunction as a very early sign of idiopathic Parkinson's disease (IPD). Aim of the present study was to clinically follow-up patients with idiopathic hyposmia to find out the percentage of patients developing IPD after 4 years time. At baseline, olfactory tests had been combined with transcranial sonography of the substantia nigra and I-123-FP-CIT SPECT imaging. At the present neurological examination, 7% of the individuals with idiopathic hyposmia had developed clinical IPD. Altogether, 13% presented with abnormalities of the motor system. Our data suggest that a combination of olfactory testing and other tests may constitute a screening tool for the risk to develop IPD. (c) 2007 Movement Disorder Society.
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