Journal
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
Volume 133, Issue 1, Pages 55-63Publisher
ELSEVIER
DOI: 10.1016/j.autneu.2007.02.001
Keywords
intestinal secretion; chloride; 5-hydroxytryptamine; enteric nerves
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Funding
- NIDDK NIH HHS [R01 DK037240-21] Funding Source: Medline
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Chloride secretion is important because it is the driving force for fluid movement into the intestinal lumen. The flow of accumulated fluid flushes out invading micro-organisms in defense of the host. Chloride secretion is regulated by neurons in the submucosal plexus of the enteric nervous system. Mechanosensitive enterochromaffin cells that release 5-bydroxytryptamine (5-HT) and activate intrinsic afferent neurons in the submucosal plexus and initiate chloride secretion. Mechanical stimulation by distention may also trigger reflexes by a direct action on intrinsic afferent neurons. Dysregulation of 5-HT release or altered activity of intrinsic afferents is likely to occur in states of inflammation and other disorders. (c) 2007 Elsevier B.V. All rights reserved.
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