Journal
DEVELOPMENTAL BIOLOGY
Volume 305, Issue 1, Pages 1-13Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2007.01.045
Keywords
epigenetic mechanisms; extracellular signaling molecules; eye development; morphogenetic mechanisms; lens induction; optic cup; optic vesicle; pattern formation; retina development; retinal pigment epithelium; transcription factors
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Funding
- NEI NIH HHS [R01 EY004859-23, R01 EY004859-19, R01 EY004859-17, P30 EY001765, R01 EY004859-20, R01 EY004859-22, R01 EY004859, EY 04859, EY 1765, R01 EY004859-21, R01 EY004859-24, R01 EY004859-18] Funding Source: Medline
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Optic vesicle formation, transformation into an optic cup and integration with neighboring tissues are essential for normal eye formation, and involve the coordinated occurrence of complex cellular and molecular events. Perhaps not surprisingly, these complex phenomena have provided fertile ground for controversial and even contradictory results and conclusions. After presenting an overview of current knowledge of optic vesicle development, we will address conceptual and methodological issues that complicate research in this field. This will be done through a review of the pertinent literature, as well as by drawing on our own experience, gathered through recent studies of both intra- and extra-cellular regulation of optic vesicle development and patterning. Finally, and without attempting to be exhaustive, we will point out some important aspects of optic vesicle development that have not yet received enough attention. (c) 2007 Elsevier Inc. All rights reserved.
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