Journal
VISION RESEARCH
Volume 47, Issue 11, Pages 1523-1536Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2007.01.017
Keywords
neurotrophic factors; visual system; dopamine; maturation; In situ hybridization
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Funding
- NEI NIH HHS [R01 EY004864, EY014764, P30 EY006360, EY004864] Funding Source: Medline
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To assess the effect of NT-4 deprivation on maturation of retinal circuitry, we investigated a mouse with targeted deletion of the gene encoding nt-4 (nt-4(-/-)). In particular, we studied neurons immunostained by an antibody recognizing tyrosine hydroxylase (TH), the rate limiting enzyme for dopamine (DA) synthesis. We found that TH immunopositive processes were altered in the retina of nt-4(-/-). Alteration of TH immunopositive processes in nt-4(-/-) mice resulted in changes of DA turnover, as assessed by high-pressure liquid chromatography measurements. These findings suggest that retinal NT-4 plays a role in the morphological maturation of dopaminergic retinal cells. (C) 2007 Elsevier Ltd. All rights reserved.
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