Journal
DEVELOPMENTAL CELL
Volume 12, Issue 5, Pages 671-682Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2007.04.005
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Funding
- NIGMS NIH HHS [R01 GM 70521, R01 GM080616] Funding Source: Medline
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Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane. However, recent findings have revealed a role for the coat in directing a vesicle to its correct intracellular destination. In this review we will discuss the literature that links coat proteins to vesicle targeting events.
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