Journal
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
Volume 92, Issue 5, Pages 694-697Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.10999
Keywords
platelet aggregation; platelet-rich plasma; platelet count
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Adjusting platelet count (PC) in platelet-rich plasma (PRP) using platelet-poor plasma (PPP) is recommended for platelet aggregation (PA) studies, but it could also affect PA independently of the decrease in PC. Analysis of aggregation tracings from healthy controls showed that PC correlated with PA in 47 diluted-PRPs, but not in 104 undiluted-PRPs. Dilution of 9 PRPs with PPP progressively decreased PA, while dilution of washed platelets with buffer hardly affected PA. Apyrase partially prevented the inhibitory effect of PPP Therefore, the practice of diluting PRP with PPP to adjust platelet count should be avoided because it artefactually inhibits PA.
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