Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 104, Issue 18, Pages 7652-7657Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0702225104
Keywords
arealization; regionalization; forebrain; protomap; neocortex
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Funding
- NIMH NIH HHS [K05 MH065670] Funding Source: Medline
- NINDS NIH HHS [R01 NS034661, NS34661-01A1] Funding Source: Medline
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The frontal cortex (FC) is the seat of higher cognition. The genetic mechanisms that control formation of the functionally distinct subdivisions of the FC are unknown. Using a set of gene expression markers that distinguish subdivisions of the newborn mouse FC, we show that loss of Fgf17 selectively reduces the size of the dorsal FC whereas ventral/orbital FC appears normal. These changes are complemented by a rostral shift of sensory cortical areas. Thus, Fgf17 functions similar to Fgf8 in patterning the overall neocortical map but has a more selective role in regulating the properties of the dorsal but not ventral FC.
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