Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 12, Issue -, Pages 4288-4297Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2388
Keywords
TFO; triplex-forming oligonucleotides; H-DNA; DNA repair; nucleotide excision repair; anti-gene; mutagenesis; homologous recombination; gene correction; review
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Funding
- NCI NIH HHS [R01CA64186] Funding Source: Medline
- NIGMS NIH HHS [5T32GM07205] Funding Source: Medline
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Triple-helix DNA structures can form endogenously at mirror repeat polypurine/polypyrimidine sequences or by introduction of triplex- forming oligonucleotides ( TFOs). Recent evidence suggests that triple helices are sources of genetic instability, and are subject to increased rates of mutagenesis and recruitment of repair factors. Indeed, observations using TFOs suggest that triple helices provoke a variety of biological processes which can be harnessed to modulate gene expression and induce heritable changes in targeted genes. This review surveys the biological applications of TFOs, with particular attention to their recombinogenic and mutagenic potential, and summarizes available evidence for the mechanism of triplex and triplex- associated repair.
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