Journal
MITOCHONDRION
Volume 7, Issue 3, Pages 211-222Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2006.11.023
Keywords
mitochondrial DNA; DNA helicase; DNA replication; DNA repair; DNA damage
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Mitochondrial DNA (mtDNA) is highly susceptible to oxidative and chemically induced damage, and these insults lead to a number of diseases. In Saccharomyces cerevisiae, the DNA helicase Pif1p is localized to the nucleus and mitochondria. We show that pif1 mutant cells are sensitive to ethidium bromide-induced damage and this mtDNA is prone to fragmentation. We also show that Pif1p associates with mtDNA. In pif1 mutant cells, mtDNA breaks at specific sites that exhibit Pif1-dependent recombination. We conclude that Pif1p participates in the protection from double-stranded (ds) DNA breaks or alternatively in the repair process of dsDNA breaks in mtDNA. (c) 2006 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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