Journal
JOURNAL OF IMMUNOLOGY
Volume 178, Issue 9, Pages 5524-5532Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.178.9.5524
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Funding
- NIDDK NIH HHS [R01 DK 43211, R01 DK 57328, F32 DK 10139] Funding Source: Medline
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T cells are key mediators of intestinal immunity, and specific T cell subsets can have differing immunoregulatory roles in animal models of mucosal inflammation. In this study, we describe human CD56(+) T cells as a morphologically distinct population expressing a mature, nonproliferative phenotype that is frequent in the gut. Enhanced potential for IFN-gamma and TNF synthesis suggested a proinflammatory function, and we directly demonstrate effector function mediated by direct T-T interaction with responder cells in vitro. CD56(+) Ir cells from peripheral blood responded to the gut-related CD2 signal, and were necessary for effective CD2-mediated proliferation of peripheral blood CD56(-) T cells. Our findings associate CD56(+) T cells with the intestinal immune compartment and suggest a putative effector function in human mucosal immunity.
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