Journal
XENOTRANSPLANTATION
Volume 14, Issue 3, Pages 198-207Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1399-3089.2007.00395.x
Keywords
CD94; HLA; E HLA-G; NK cell; NKG2A; NKG2D; xenotransplantation
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Funding
- NIAID NIH HHS [AI067814] Funding Source: Medline
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Human NK cell-mediated graft rejection is likely to be one of several biological obstacles to routine pig-to-human xenotransplantation. Abrogating NK cell activation by either elimination of activating ligands on porcine cells or expression of molecules serving as ligands for NK cell inhibitory receptors, or both, could overcome this hurdle. HLA-E and -G exhibit very limited polymorphism and are ligands for NK cell inhibitory receptors. This review summarizes successes and limitations of their use in xenotransplantation as inferred from ex vivo analyses of NK cell activity, highlights potential effects they may have on T-cell responses, and considers prospects of preclinical trials and potential outcomes.
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