Journal
CLINICAL BIOCHEMISTRY
Volume 40, Issue 8, Pages 511-520Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2007.01.002
Keywords
cystic fibrosis omega 3; docosahexaenoic acid; essential fatty acids monitoring
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Essential fatty acid deficiency has been increasingly reported in patients with cystic fibrosis. The purpose of this work is to critically surninarize previous data on fatty acid status and omega 3 supplementation in cystic fibrosis. Although the reported abnormalities differ from study to Study, the two most consistent features appeared to be reduced circulating levels of linoleic acid and docosahexaenoic acid (DHA). On the assumption that the fatty acid composition of erythrocyte cell membranes may be similar to that of other organs, it seems appropriate to monitor the phospholipid profile from erythrocyte membranes together with circulating blood levels. Formulations containing widely variable DHA doses, ranging from 300 mg to 5 g per day, have been administered to patients with cystic fibrosis with discrepant outcomes. Randomized controlled trials are needed in order to draw firm conclusions on the therapeutic effect of omega 3 fatty acid supplementation in cystic fibrosis. (c) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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