CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock

Heterodimers of CLOCK and BMAL1, bHLH-PAS transcription factors, are believed to be the major transcriptional regulators of the circadian clock mechanism in mammals. However, a recent study shows that CLOCK-deficient mice continue to exhibit robust behavioral and molecular rhythms. Here we report that the transcription factor NPAS2 ( MOP4) is able to functionally substitute for CLOCK in the master brain clock in mice to regulate circadian rhythmicity.