Journal
MOLECULAR IMAGING AND BIOLOGY
Volume 9, Issue 3, Pages 117-125Publisher
SPRINGER
DOI: 10.1007/s11307-007-0077-4
Keywords
NNC 112; SCH 23390; dopamine D-1 receptor; serotonin 2A receptor; position emission tomography; in vivo selectivity
Ask authors/readers for more resources
Purpose: [C-11] NNC 112 and [C-11] SCH 23390 are selective positron emission tomography ( PET) tracers for visualizing dopamine D-1 receptors. It is known that both have some affinity for serotonin 2A receptors, but previous studies have suggested this is negligible compared to D-1 affinity. We sought to verify this property in vivo. Procedures: Two baboons were scanned to measure the selectivity of both tracers with a displacement paradigm. Four baboons were scanned to directly assess [C-11] NNC 112 affinity for both receptors. Results: In vivo, D-1 to 5-HT2A selectivity is six to fourteenfold, not 100-fold as previously reported by other investigators. Conclusion: We conclude that about 1/4 of the cortical signal of both [C-11] NNC 112 and [C-11] SCH 23390 is due to binding to 5-HT2A receptors. If confirmed in humans, this suggests caution should be exercised when drawing conclusions from studies using either tracer. These results also indicate the need for more selective tracers for the D-1 receptor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available