Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 17, Issue 9, Pages 2608-2613Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.01.112
Keywords
cholesteryl ester transfer protein; CETP; HDL; tetrahydoquinoxalines; cholesterol
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Cholesteryl ester transfer protein is a plasma glycoprotein that transfers cholesterol ester between lipoprotein particles. Inhibition of this protein, in vitro and in vivo, produces an increase in plasma high density lipoprotein cholesterol (HE)L-Q. This communication will describe the SAR and svnthesis of a series of substituted tetrahydroquinoxaline CETP inhibitors from early P lead to advanced enantiomerically pure anaiogs. (c) 2007 Elsevier Ltd. All rights reserved.
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