Journal
PEDIATRIC RESEARCH
Volume 61, Issue 5, Pages 58R-63RPublisher
INT PEDIATRIC RESEARCH FOUNDATION, INC
DOI: 10.1203/pdr.0b013e3180457635
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Funding
- NIMH NIH HHS [F31 MH70204] Funding Source: Medline
- NINDS NIH HHS [R01 NS44405, R01 NS51411] Funding Source: Medline
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The development and function of the CNS requires accurate gene transcription control in response to proper environmental signals. Epigenetic mechanisms, including DNA methylation, histone modifications, and other chromatin-remodeling events, are critically important in mediating precise neural gene regulation. This review focuses on discussing the role of DNA methylation and histone modifications in neural lineage differentiation, synaptic plasticity and neural behavior. We postulate that DNA methylation-and histone modification-mediated gene regulation is not only important for neural cell differentiation but also crucial for high-order cognitive functions such as learning and memory.
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