Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 7, Issue 5, Pages 481-489Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955707780619626
Keywords
quinones; anticancer agents; tumor-selective toxicity; SAR; prodrugs; heterocycles
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The development of prodrugs that are enzymatically activated into anticancer agents is a promising perspective in cancer therapy. Many nitrogen-containing quinoid heterocycles have been reported to show antitumor effect. The principal interest in these compounds lies on their potential to produce tumor-selective toxicity. Selectivity occurs by difference in oxygen tension between normal and tumor tissue and by levels of the required activating enzymes.
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