Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 850, Issue 1-2, Pages 515-522Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2006.12.045
Keywords
Delta(9)-tetrahydrocannabinol; 11-hydroxy-Delta(9)-tetrahydrocannabinol; 11-nor-Delta(9)-tetrahydrocannabinol-9-carboxylic acid; cannabidiol; cannabinol; cannabinoids; LC/MS/MS; APCI; human EDTA-plasma; human urine
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A novel high-performance liquid chromatographic separation method with tandem-mass spectrometry detection was developed for the simultaneous determination of Delta(9)-tetrahydrocannabinol (THC) and its major metabolites 11-hydroxy-Delta(9)-tetrahydrocannabinol (11-OH-THC) and 11-nor-Delta(9)-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) as well as the components cannabidiol (CBD) and cannabinol (CBN) in human EDTA-plasma and urine. Run time was 25 min. Lower limit of quantification was 0.2 ng/ml. The coefficients of variation of all inter- and intra-assay determinations were between 1.3 and 15.5%. The method was successfully applied to the determination of cannabinoids in human plasma and human urine after administration of Delta(9)-tetrahydrocannabinol or Cannabis sativa extracts. (c) 2007 Elsevier B.V. All rights reserved.
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