Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
Volume 1769, Issue 5-6, Pages 346-357Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbaexp.2006.12.004
Keywords
plant chromatin; high mobility group (HMG) protein; transcription; DNA-binding; architectural factor; nucleoprotein complex
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In plants, the chromosomal high mobility group (HMG) proteins of the HMGB family typically contain a central HMG-box DNA-binding domain that is flanked by a basic N-terminal and an acidic C-terminal domain. The HMGB proteins are abundant and highly mobile proteins in the cell nucleus that influence chromatin structure and enhance the accessibility of binding sites to regulatory factors. Due to their remarkable DNA bending activity, HMGB proteins can increase the structural flexibility of DNA, promoting the assembly of nucleoprotein complexes that control DNA-dependent processes including transcription. Therefore, members of the HMGB family act as versatile modulators of chromatin function. (c) 2007 Elsevier B.V. All rights reserved.
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