Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 103, Issue 1, Pages 23-28Publisher
SPRINGER
DOI: 10.1007/s10549-006-9347-0
Keywords
lymphatic drainage; imaging; breast cancer; lymph node; lymphedema; nanotechnology; quantum dots; spectral fluorescence imaging; near infrared
Categories
Funding
- Intramural NIH HHS Funding Source: Medline
Ask authors/readers for more resources
Due to their small size and poor access, the lymphatic function has been difficult to study in vivo. Especially difficult is the mapping of lymphatic drainage from two basins into the same node. Quantum dots can be used to perform multicolor images with high fluorescent intensity and are of a nano-size size suitable for lymphatic imaging via direct interstitial injection. Here we show simultaneous two-color in vivo wavelength-resolved spectral fluorescence lymphangiography using two near infrared quantum dots with different emission spectra, which allow non-invasive and simultaneous visualization of two separate lymphatic flows draining the breast and the upper extremity and variations in the drainage patterns and the water sheds within the axillary node. Two-color spectral fluorescence lymphangiography can provide insight into mechanisms of drainage from different lymphatic basins that may lead to sentinel lymph nodes detection of the breast cancer as well as prevention of complications such as lymphedema of the arm.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available