Journal
EXPERIMENTAL GERONTOLOGY
Volume 42, Issue 5, Pages 438-440Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2006.10.012
Keywords
aging immune system; vaccinations; CD4 T cells
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Funding
- NIA NIH HHS [R01 AG021054, P01 AG021600] Funding Source: Medline
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The elderly exhibit reduced responses to vaccinations, leaving them more susceptible to preventable infectious diseases such as influenza and pneumonia. It has been unclear as to the specific changes in the aging immune system that contribute to this decline, thus we have developed a mouse model to examine this phenomenon and determine why it occurs and how it can be overcome. Our ultimate goal is to determine how to enhance vaccine efficacy for elderly populations. (C) 2006 Elsevier Inc. All rights reserved.
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