Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 11, Issue 5, Pages 707-716Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.11.5.707
Keywords
cell survival; phosphatidic acid; phospholipase D; vesicle trafficking
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Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Genetic and pharmacological methods have implicated PLD and its product PA in a wide variety of cellular processes including vesicle trafficking, receptor signaling, cell proliferation and survival. Dysregulation of these cell biologic processes occurs in a diverse range of illnesses including cancer. This review summarizes PLD regulation and function and highlights its potential as a therapeutic target in disease settings.
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