Journal
APOPTOSIS
Volume 12, Issue 5, Pages 951-968Publisher
SPRINGER
DOI: 10.1007/s10495-007-0719-7
Keywords
apoptosis; calcium; endoplasmic reticulum; IP3; IP3 receptor; mitochondria
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Funding
- NIDDK NIH HHS [DK 51526, DK 34804] Funding Source: Medline
- NIGMS NIH HHS [GM 59419] Funding Source: Medline
- NINDS NIH HHS [NS 51822] Funding Source: Medline
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Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) serve to discharge Ca2+ from ER stores in response to agonist stimulation. The present review summarizes the role of these receptors in models of Ca2+-dependent apoptosis. In particular we focus on the regulation of IP(3)Rs by caspase-3 cleavage, cytochrome c, anti-apoptotic proteins and Akt kinase. We also address the evidence that some of the effects of IP(3)Rs in apoptosis may be independent of their ion-channel function. The role of IP(3)Rs in delivering Ca2+ to the mitochondria is discussed from the perspective of the factors determining inter-organellar dynamics and the spatial proximity of mitochondria and ER membranes.
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