Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 12, Issue -, Pages 3468-3474Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2327
Keywords
tumor microenvironment; cancer; cancer therapy; stromal-epithelial interaction; review
Categories
Funding
- NCI NIH HHS [R01 CA064786, R37 CA064786, R01 CA057621, CA64786, CA57621, R01 CA064786-07, R01 CA057621-07] Funding Source: Medline
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Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the druggable targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.
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