Journal
INTERNATIONAL JOURNAL OF NEUROSCIENCE
Volume 117, Issue 5, Pages 617-625Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00207450600773806
Keywords
C-fiber reflex; glia; interleukin-1 beta; pain; propentofylline; spinal cord; wind-up
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To investigate the contribution of glial cells in the spinal cord nociceptive transmission, the effect of intrathecally administered interleukin-1 beta (IL-1 beta) was studied in rats treated with the glial cell inactivator propentotylline and submitted to a C-fiber-mediated reflex paradigm evoked by single and repetitive (wind-up) electric stimulation, Intrathecal IL-1 beta did not modify the C reflex integrated activity in either group of animals, while producing increased wind-up in intact and decreased wind-up in propentofylline pre-treated rats. Results suggest that the excitatory effect of IL-1 beta on spinal wind-up activity in healthy rats is produced by a glial mediator, whereas the inhibitory effect resulted from a direct effect of the cytokine on dorsal horn neurons.
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