Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 12, Issue -, Pages 4298-4314Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2389
Keywords
tumour-associated macrophage; TAM; angiogenesis; hypoxia; immunosuppression; migration; metastasis; therapy; review
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One characteristic of solid tumour tissue is the presence of large numbers of tumour-associated macrophages. These migrate down gradients of chemo-attractive agents to accumulate within hypoxic and / or necrotic areas where they are generally related to poor clinical prognosis. In this review we will discuss the molecular mechanisms that underlie recruitment of macrophages into tumours and their pro- tumourigenic activities with respect to stimulation of angiogenesis, lymphangiogenesis, tumour cell migration, metastasis and immuno- suppression. The potential of macrophage- related anticancer therapies will be discussed in the light of this phenotype.
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